Significato prognostico dell’interessamento dei margini di resezione dopo gastrectomia per carcinoma: esperienza monocentrica

Curative gastrectomy represents the treatment of choice for gastric cancer. A variety of clinicopathologic features, such as resection line involvement (RLI) has been suggested as prognostic indicators for gastric cancer. The aim of this study was to investigate whether microscopic positive margins are detrimental to the outcome of gastric cancer patients treated with gastrectomy. Methods: Among 1087 consecutive patients who had undergone gastrectomy with curative intent for gastric cancer between January 1990 and December 2008, 116 patients (10,7%) had positive resection margins on final histology. Results: Among these 116 patients, 48 had proximal and distal involved margins, 33 had proximal involved margins, and 35 had distal involved margins. No one patient had reoperation. The mean distance between proximal gastric margin and the neoplasia was 4±3,8 (min 0, max 21) and from the distal margin and the neoplasia 4±3.9 (min 0, max 24). The negative margin group had a significantly longer median survival time (P