Nicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in important processes such as learning and memory, and are therapeutic targets for neural diseases. The α7 nAChR has been implicated in Alzheimer's disease and schizophrenia, and allosteric modulators have become one focus of drug development efforts. We investigate the mode of action of the α7-selective positive allosteric modulator, PNU-120596, and show that the higher potency of acetylcholine in the presence of PNU-120596 is not due to an altered agonist binding site. In addition, we propose several residues in the gating interface and transmembrane region that are functionally important to transduction of allosteric properties, and link PNU-12059...
AbstractAcetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding at an extracel...
Neuronal nicotinic receptors (nAChRs) have been implicated in several diseases and disorders such as...
The α7 nicotinic acetylcholine receptor is a pentameric ligand gated ion channel. It is widely expre...
SummaryNicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in...
Nicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in import...
Nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including ni...
Positive allosteric modulators of alpha7 nicotinic acetylcholine receptors (nAChRs) have attracted c...
AbstractPositive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have att...
Abstract Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have po...
Nicotinic acetylcholine receptors (nAChRs) belong to the family of pentameric ligand-gated ion chann...
The α7 nicotinic acetylcholine receptor (nAChR) belongs to the family of pentameric ligand-gated ion...
The alpha7 nicotinic acetylcholine receptor (nAChR), a homopentameric, rapidly activating and desens...
The neuronal nicotinic acetylcholine receptor (nAChR) is one of the most important ligand-gate ion c...
Nicotinic acetylcholine receptors (AChRs) are the best characterized ion channels representing the C...
In this study we take advantage of a recently described chimera of the α7 nicotinic acetylcholine re...
AbstractAcetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding at an extracel...
Neuronal nicotinic receptors (nAChRs) have been implicated in several diseases and disorders such as...
The α7 nicotinic acetylcholine receptor is a pentameric ligand gated ion channel. It is widely expre...
SummaryNicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in...
Nicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in import...
Nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including ni...
Positive allosteric modulators of alpha7 nicotinic acetylcholine receptors (nAChRs) have attracted c...
AbstractPositive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have att...
Abstract Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have po...
Nicotinic acetylcholine receptors (nAChRs) belong to the family of pentameric ligand-gated ion chann...
The α7 nicotinic acetylcholine receptor (nAChR) belongs to the family of pentameric ligand-gated ion...
The alpha7 nicotinic acetylcholine receptor (nAChR), a homopentameric, rapidly activating and desens...
The neuronal nicotinic acetylcholine receptor (nAChR) is one of the most important ligand-gate ion c...
Nicotinic acetylcholine receptors (AChRs) are the best characterized ion channels representing the C...
In this study we take advantage of a recently described chimera of the α7 nicotinic acetylcholine re...
AbstractAcetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding at an extracel...
Neuronal nicotinic receptors (nAChRs) have been implicated in several diseases and disorders such as...
The α7 nicotinic acetylcholine receptor is a pentameric ligand gated ion channel. It is widely expre...