MicroRNA-125b Represses IRF4 to Induce Acute Myeloid Leukemia
- Chaudhuri, A.
- So, A. Y.
- Sookram, R.
- Baltimore, D.
DOIAbstract
MicroRNA-125b (miR-125b) is upregulated in a variety of neoplastic blood disorders. We previously showed that miR-125b expression is enriched in hematopoietic stem and progenitor cells (HSPCs), and that upregulation of miR-125b in the mouse hematopoietic system causes an aggressive acute myeloid leukemia. Here we elucidate the molecular mechanism by which miR-125b causes acute myeloid leukemia
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