The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease
- Hoffmann, H J
- Santos, A F
- Mayorga, C
- Nopp, A
- Eberlein, B
- Ferrer, M
- Rouzaire, P
- Ebo, D G
- Sabato, V
- Sanz, M L
- Pecaric-Petkovic, T
- Patil, S U
- Hausmann, Oliver
- Shreffler, W G
- Korosec, P
- Knol, E F
DOIAbstract
The basophil activation test (BAT) has become a pervasive test for allergic response through the development of flow cytometry, discovery of activation markers such as CD63 and unique markers identifying basophil granulocytes. Basophil activation test measures basophil response to allergen cross-linking IgE on between 150 and 2000 basophil granulocytes in <0.1 ml fresh blood. Dichotomous activation is assessed as the fraction of reacting basophils. In addition to clinical history, skin prick test, and specific IgE determination, BAT can be a part of the diagnostic evaluation of patients with food-, insect venom-, and drug allergy and chronic urticaria. It may be helpful in determining the clinically relevant allergen. Basophil sensitivity m...
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