Clinical outcomes and revascularization strategies in patients with low-flow, low-gradient severe aortic valve stenosis according to the assigned treatment modality
- O'Sullivan, Crochan J.
- Englberger, Lars
- Hosek, Nicola
- Heg, Dik
- Cao, Davide
- Stefanini, Giulio
- Stortecky, Stefan
- Glökler, Steffen
- Spitzer, Ernest
- Tüller, David
- Huber, Christoph
- Pilgrim, Thomas
- Praz, Fabien
- Büllesfeld, Lutz
- Khattab, Ahmed A.
- Carrel, Thierry
- Meier, Bernhard
- Windecker, Stephan
- Wenaweser, Peter Martin
DOIAbstract
OBJECTIVES This study compared clinical outcomes and revascularization strategies among patients presenting with low ejection fraction, low-gradient (LEF-LG) severe aortic stenosis (AS) according to the assigned treatment modality. BACKGROUND The optimal treatment modality for patients with LEF-LG severe AS and concomitant coronary artery disease (CAD) requiring revascularization is unknown. METHODS Of 1,551 patients, 204 with LEF-LG severe AS (aortic valve area <1.0 cm(2), ejection fraction <50%, and mean gradient <40 mm Hg) were allocated to medical therapy (MT) (n = 44), surgical aortic valve replacement (SAVR) (n = 52), or transcatheter aortic valve replacement (TAVR) (n = 108). CAD complexity was assessed using the SYNTA...
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