Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume
- Conductier, Grégory
- Brau, Frédéric
- Viola, Angèle
- Langlet, Fanny
- Ramkumar, Navean
- Dehouck, Bénédicte
- Lemaire, Thibault
- Chapot, Raphaël
- Lucas, Laurianne
- Rovère, Carole
- Maitre, Priscilla
- Hosseiny, Salma
- Petit-Paitel, Agnès
- Adamantidis, Antoine Roger
- Lakaye, Bernard
- Risold, Pierre-Yves
- Prévot, Vincent
- Meste, Olivier
- Nahon, Jean-Louis
- Guyon, Alice
Publication date
July 2013
DOI Publisher
Springer Science and Business Media LLC ISSN
1097-6256 Citation count (estimate)
24Abstract
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase
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