IV thrombolysis and renal function
- Gensicke, Henrik
- Zinkstok, Sanne M.
- Roos, Yvo B.
- Seiffge, David J.
- Ringleb, Peter
- Artto, Ville
- Putaala, Jukka
- Haapaniemi, Elena
- Leys, Didier
- Bordet, Régis
- Michel, Patrik
- Odier, Céline
- Berrouschot, Jörg
- Arnold, Marcel
- Heldner, Mirjam Rachel
- Zini, Andrea
- Bigliardi, Guido
- Padjen, Visnja
- Peters, Nils
- Pezzini, Alessandro
- Schindler, Christian
- Sarikaya, Hakan
- Bonati, Leo H.
- Tatlisumak, Turgut
- Lyrer, Philippe
- Nederkoorn, Paul J.
- Engelter, Stefan T.
DOIAbstract
OBJECTIVE To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT). METHODS In this observational study, we compared the estimated glomerular filtration rate (GFR) with poor 3-month outcome (modified Rankin Scale scores 3-6), death, and symptomatic intracranial hemorrhage (sICH) based on the criteria of the European Cooperative Acute Stroke Study II trial. Unadjusted and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Patients without IVT treatment served as a comparison group. RESULTS Among 4,780 IVT-treated patients, 1,217 (25.5%) had a low GFR (<60 mL/min/1.73 m(2)). A GFR decrease by 10 mL/min/1.73 m(2) ...
Add to ORKG