BACKGROUND: The surfactant proteins B (SP-B) and C (SP-C) are important for the stability and function of the alveolar surfactant film. Their involvement and down-regulation in inflammatory processes has recently been proposed, but their level during neutrophilic human airway diseases are not yet known. METHODS: We used 1D-electrophoresis and Western blotting to determine the concentrations and molecular forms of SP-B and SP-C in bronchoalveolar lavage (BAL) fluid of children with different inflammatory airway diseases. 21 children with cystic fibrosis, 15 with chronic bronchitis and 14 with pneumonia were included and compared to 14 healthy control children. RESULTS: SP-B was detected in BAL of all 64 patients, whereas SP-C was found in BA...
Influenza A virus (IAV) is a major cause of morbidity and mortality worldwide. Surfactant proteins A...
Infection with respiratory syncytial virus (RSV) is a common cause of respiratory disease in infancy...
Lung surfactant is a complex mixture of phospholipids and proteins with the main function to reduce ...
The pulmonary collectins surfactant protein (SP)-A and SP-D play important roles in innate lung defe...
BACKGROUND: Children's interstitial lung diseases (chlLD) comprise a broad spectrum of diseases. Bes...
Background: Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-...
Interstitial lung diseases often are accompanied by histopathologic evidence of alveolar type 2 cell...
Pulmonary surfactant is a complex lipid-protein mixture lining the pulmonary epithelium. Although it...
Background: Allergic asthma is associated with airway inflammation and dysfunction of pulmonary surf...
Surfactant protein B (SP B), a highly hydrophobic surfactant-associated protein, was isolated from l...
AbstractThe abundant and restricted expression of surfactant proteins SP-A and SP-D within the lung ...
Objective To determine bronchoalveolar lavage (BAL) levels of 3 innate immunity components (human al...
Alterations to pulmonary surfactant structure, composition, and function contribute to the severity ...
Transformations of surfactant after secretion are incompletely understood. To clarify them, we lavag...
Community-acquired pneumonia is one of the most common infectious diseases and remains one of the le...
Influenza A virus (IAV) is a major cause of morbidity and mortality worldwide. Surfactant proteins A...
Infection with respiratory syncytial virus (RSV) is a common cause of respiratory disease in infancy...
Lung surfactant is a complex mixture of phospholipids and proteins with the main function to reduce ...
The pulmonary collectins surfactant protein (SP)-A and SP-D play important roles in innate lung defe...
BACKGROUND: Children's interstitial lung diseases (chlLD) comprise a broad spectrum of diseases. Bes...
Background: Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-...
Interstitial lung diseases often are accompanied by histopathologic evidence of alveolar type 2 cell...
Pulmonary surfactant is a complex lipid-protein mixture lining the pulmonary epithelium. Although it...
Background: Allergic asthma is associated with airway inflammation and dysfunction of pulmonary surf...
Surfactant protein B (SP B), a highly hydrophobic surfactant-associated protein, was isolated from l...
AbstractThe abundant and restricted expression of surfactant proteins SP-A and SP-D within the lung ...
Objective To determine bronchoalveolar lavage (BAL) levels of 3 innate immunity components (human al...
Alterations to pulmonary surfactant structure, composition, and function contribute to the severity ...
Transformations of surfactant after secretion are incompletely understood. To clarify them, we lavag...
Community-acquired pneumonia is one of the most common infectious diseases and remains one of the le...
Influenza A virus (IAV) is a major cause of morbidity and mortality worldwide. Surfactant proteins A...
Infection with respiratory syncytial virus (RSV) is a common cause of respiratory disease in infancy...
Lung surfactant is a complex mixture of phospholipids and proteins with the main function to reduce ...