Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2
- Regel, Ivonne
- Merkl, Lisa
- Friedrich, Teresa
- Burgermeister, Elke
- Zimmermann, Wolfgang
- Einwächter, Henrik
- Herrmann, Ken
- Langer, Rupert
- Röcken, Christoph
- Hofheinz, Ralf
- Schmid, Roland
- Ebert, Matthias P
Publication date
January 2012
DOI Publisher
Elsevier BV ISSN
0016-5085 Citation count (estimate)
17Abstract
Chemotherapy modestly prolongs survival of patients with advanced gastric cancer, but strategies are needed to increase its efficacy. Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote apoptosis
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