LFA-1 expression in a series of colorectal adenocarcinomas
- Papas, Maria G
- Karatzas, Pantelis S
- Papanikolaou, Ioannis S
- Karamitopoulou, Evanthia
- Delicha, Eumorphia M
- Adler, Andreas
- Triantafyllou, Konstantinos
- Thomopoulou, Georgia-Heleni
- Patsouris, Efstratios
- Lazaris, Andreas C
Publication date
January 2012
DOI Publisher
Springer Science and Business Media LLCAbstract
LFA-1 is an adhesion molecule which belongs to the β2-integrin family. Overexpression of LFA-1 in hepatic natural killer cells has been associated with increased apoptosis of neoplastic cells in colorectal cancer (CRC); moreover, studies in CRC have linked LFA-1 overexpression in neoplastic cells with vascular intrusion through adhesion to endothelial cells, thus implying a possible role in creation of metastases
Add to ORKG