RASAGILINE INTERFERES WITH NEURODEGENERATION IN THE PRPH2/RDS MOUSE

Eigeldinger-Berthou, Sylvie
Meier, Claudia
Zulliger, Rahel
Lecaudé, Stéphanie
Enzmann, Volker
Sarra, Gian-Marco

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Publication date

January 2012

DOI

10.1097/IAE.0b013e31821e2070

Publisher

Ovid Technologies (Wolters Kluwer Health)

ISSN

0275-004X

Abstract

Rasagiline (N-propargyl-1(R)-aminoindan) is a second-generation propargylamine with neuroprotective effects. We used the Prph2/rds mouse to assess the effect of rasagiline on photoreceptor cell death and to examine the possible modulation of different pathways of programmed cell death