Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors
- Pham, Hung
- Chen, Monica
- Li, Aihua
- King, Jonathan
- Angst, Eliane
- Dawson, David W.
- Park, Jenny
- Reber, Howard A.
- Hines, O. Joe
- Eibl, Guido
Publication date
January 2010
DOI Publisher
Ovid Technologies (Wolters Kluwer Health) ISSN
0885-3177 Citation count (estimate)
25Abstract
Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Down-regulation of PGDH contributes to PGE2 accumulation in lung and colon cancers but has not been identified in pancreatic cancer
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