Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, ...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
Unlike the circular structure of prokaryotic chromosome, the structure of eukaryotic chromosomes is ...
Telomeres are the components of chromosome ends that provide stability and allow the complete replic...
Telomeres, the protective structures of chromosome ends are gradually shortened by each cell divisio...
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for geno...
High telomerase activity is detected in nearly all human cancers but most human cells are devoid of ...
The overall goal of this collaborative project was to investigate the role in malignant cells of bot...
Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of repli...
Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of repli...
Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant leng...
The linear ends of chromosome are protected by specialized ribonucleoprotein (RNP) termed as telomer...
Telomeres are repetitive TTAGGG structures ending each chromosome and thereby protecting its integri...
Cancer is a leading cause of death worldwide, with approximately 18.1 million new cases and 9.6 mill...
Major advances have been made in understanding the role of telomerase in cellular immortalization an...
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, ...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
Unlike the circular structure of prokaryotic chromosome, the structure of eukaryotic chromosomes is ...
Telomeres are the components of chromosome ends that provide stability and allow the complete replic...
Telomeres, the protective structures of chromosome ends are gradually shortened by each cell divisio...
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for geno...
High telomerase activity is detected in nearly all human cancers but most human cells are devoid of ...
The overall goal of this collaborative project was to investigate the role in malignant cells of bot...
Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of repli...
Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of repli...
Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant leng...
The linear ends of chromosome are protected by specialized ribonucleoprotein (RNP) termed as telomer...
Telomeres are repetitive TTAGGG structures ending each chromosome and thereby protecting its integri...
Cancer is a leading cause of death worldwide, with approximately 18.1 million new cases and 9.6 mill...
Major advances have been made in understanding the role of telomerase in cellular immortalization an...
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, ...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
Unlike the circular structure of prokaryotic chromosome, the structure of eukaryotic chromosomes is ...
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