The present study investigated the effects of chronic, repeated hypoxia during a postnatal vulnerable period. Acoustic startle response in adult rats was measured along with NMDA receptor binding and mRNA expression of subunits at postnatal days (PND) 11 and 120. Rats at PND 120 exhibited a deficit in prepulse inhibition of acoustic startle response. In PND 11 rats, chronic hypoxia decreased NMDA receptor binding and increased transcript expression of NR1 subunit in frontal and temporal regions, nucleus accumbens and hippocampus, while NR2A subunit expression was downregulated in hippocampal subregions. At PND 120, gene expression of NR1 was still increased in hippocampal, frontal and temporal subregions as well as nucleus accumbens. A prep...
Interactions between genetic and environmental risk factors take center stage in the pathology of sc...
Perinatal cerebral hypoxia represents a major cause of obstetric complications and the resulting tra...
Epidemiological studies suggest that obstetric complications, particularly those related to hypoxia ...
The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and ...
The brain-derived neurotrophic factor (BDNF) is a major proliferative agent in the nervous system. B...
As a consequence of obstetric complications, neonatal hypoxia has been discussed as an environmental...
Obstetric complications play a role in the pathophysiology of schizophrenia. However, the biological...
Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including ...
Recently, it has been suggested that neurodevelopmental abnormalities underlie schizophrenia. Howev...
Our work is focused on the role of NR1 subunit of N-methyl-D-aspartate receptor in pathophysiology o...
It is well accepted that events that interfere with the normal program of neuronal differentiation a...
INTRODUCTION: As a consequence of obstetric complications hypoxia has been discussed as a possible f...
It is well accepted that events that interfere with the normal program of neuronal differentiation a...
<div><p>Pharmacological and genetic studies support a role for NMDA receptor (NMDAR) hypofunction in...
Obstetric complications have been regarded as a risk factor for schizophrenia later in life. One of ...
Interactions between genetic and environmental risk factors take center stage in the pathology of sc...
Perinatal cerebral hypoxia represents a major cause of obstetric complications and the resulting tra...
Epidemiological studies suggest that obstetric complications, particularly those related to hypoxia ...
The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and ...
The brain-derived neurotrophic factor (BDNF) is a major proliferative agent in the nervous system. B...
As a consequence of obstetric complications, neonatal hypoxia has been discussed as an environmental...
Obstetric complications play a role in the pathophysiology of schizophrenia. However, the biological...
Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including ...
Recently, it has been suggested that neurodevelopmental abnormalities underlie schizophrenia. Howev...
Our work is focused on the role of NR1 subunit of N-methyl-D-aspartate receptor in pathophysiology o...
It is well accepted that events that interfere with the normal program of neuronal differentiation a...
INTRODUCTION: As a consequence of obstetric complications hypoxia has been discussed as a possible f...
It is well accepted that events that interfere with the normal program of neuronal differentiation a...
<div><p>Pharmacological and genetic studies support a role for NMDA receptor (NMDAR) hypofunction in...
Obstetric complications have been regarded as a risk factor for schizophrenia later in life. One of ...
Interactions between genetic and environmental risk factors take center stage in the pathology of sc...
Perinatal cerebral hypoxia represents a major cause of obstetric complications and the resulting tra...
Epidemiological studies suggest that obstetric complications, particularly those related to hypoxia ...