The tumor suppressor protein p53 plays an important role in maternal reproduction in mice through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for blastocyst implantation. To determine whether these observations could be extended to humans, a list of single-nucleotide polymorphisms (SNPs) in the p53 pathway that can modify the function of p53 was assembled and used to study their impact on human fertility. The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients. The P72 allele serves as a risk factor for implantation failure. LIF levels are significantly lower in cells with the P72 allele...
The p53 tumor suppressor pathway is central both in reducing cancer frequency in ver-tebrates and in...
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reduc...
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reduc...
The roles of the p53 protein in tumor suppression have been firmly established. However, the functio...
Studies on human fertility genes have identified numerous risk/protective alleles involved in the oc...
Recently numerous polymorphic fertility genes have been associated with reproductive system diseases...
The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it b...
AbstractThe tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore r...
To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP3...
About 30 % of all infertile couples suffer from infertility of an unexplained cause. Leukemia inhibi...
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect...
The p53 pathway constitutes a major cellular gene network that is crucial in directing the suppressi...
A new approach to identifying genetic causes of human infertility is unveiled in a new study [1]. Th...
The p53 family and its regulatory pathway play an important role as regulators of developmental proc...
The tumor suppressor gene p53 plays an important role in the stress response of the cell and is muta...
The p53 tumor suppressor pathway is central both in reducing cancer frequency in ver-tebrates and in...
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reduc...
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reduc...
The roles of the p53 protein in tumor suppression have been firmly established. However, the functio...
Studies on human fertility genes have identified numerous risk/protective alleles involved in the oc...
Recently numerous polymorphic fertility genes have been associated with reproductive system diseases...
The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it b...
AbstractThe tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore r...
To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP3...
About 30 % of all infertile couples suffer from infertility of an unexplained cause. Leukemia inhibi...
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect...
The p53 pathway constitutes a major cellular gene network that is crucial in directing the suppressi...
A new approach to identifying genetic causes of human infertility is unveiled in a new study [1]. Th...
The p53 family and its regulatory pathway play an important role as regulators of developmental proc...
The tumor suppressor gene p53 plays an important role in the stress response of the cell and is muta...
The p53 tumor suppressor pathway is central both in reducing cancer frequency in ver-tebrates and in...
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reduc...
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reduc...