The knockout mouse project
- Austin, C. P.
- Battey, J. F.
- Bradley, A.
- Bucan, M.
- Capecchi, M.
- Collins, F. S.
- Dove, W. F.
- Duyk, G.
- Dymecki, S.
- Eppig, J. T.
- Grieder, F. B.
- Heintz, N.
- Hicks, G.
- Insel, T. R.
- Joyner, A.
- Koller, B. H.
- Lloyd, K. C. K.
- Magnuson, T.
- Moore, M. W.
- Nagy, A.
- Pollock, J. D.
- Roses, A. D.
- Sands, A. T.
- Seed, B.
- Skarnes, W. C.
- Snoddy, J.
- Soriano, P.
- Stewart, D. J.
- Stewart, F.
- Stillman, B.
- Varmus, H.
- Varticovski, L.
- Verma, I. M.
- Vogt, T. F.
- von Melchner, H.
- Witkowski, J.
- Woychik, R. P.
- Wurst, W.
- Yancopoulos, G. D.
- Young, S. G.
- Zambrowicz, B.
Publication date
September 2004
DOI Publisher
Springer Science and Business Media LLC ISSN
1061-4036 Citation count (estimate)
457Abstract
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain
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