Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin I mutation Gly203Ser () is associated with increased mitochondrial metabolic activity, consistent with the human condition. These alterations precede development of the cardiomyopathy. Here we examine the efficacy of in vivo treatment of mice with a peptide derived against the α-interaction domain of the cardiac L-type calcium channel (AID-TAT) on restoring mitochondrial metabolic activity, and preventing HCM. or age-matched mice were treated with active or inactive AID-TAT. Following treatment, targeted metabolomics was utilized to evaluate myocardial substrate m...
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder that associates with nucleotide ...
Aims: Previous studies have shown that hypertrophic cardiomyopathy mutation carriers have a decrease...
AIMS: Heart disease is commonly associated with altered mitochondrial function and signs of oxidativ...
SummaryHeterozygous mice (αMHC403/+) expressing the human disease-causing mutation Arg403Gln exhibit...
ObjectivesThe aim of this study was to establish reversibility of cardiac phenotypes in hypertrophic...
Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease characterized by left v...
Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct b...
Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct b...
Abstract Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We investig...
BACKGROUND: Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused ...
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainl...
BackgroundHypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of ...
Background Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused b...
A growing line of evidence indicates dysfunctional ubiquitin-proteasome system (UPS) in cardiac dise...
The overarching focus of this thesis is on the molecular underpinnings of inherited cardiomyopathies...
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder that associates with nucleotide ...
Aims: Previous studies have shown that hypertrophic cardiomyopathy mutation carriers have a decrease...
AIMS: Heart disease is commonly associated with altered mitochondrial function and signs of oxidativ...
SummaryHeterozygous mice (αMHC403/+) expressing the human disease-causing mutation Arg403Gln exhibit...
ObjectivesThe aim of this study was to establish reversibility of cardiac phenotypes in hypertrophic...
Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease characterized by left v...
Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct b...
Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct b...
Abstract Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We investig...
BACKGROUND: Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused ...
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainl...
BackgroundHypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of ...
Background Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused b...
A growing line of evidence indicates dysfunctional ubiquitin-proteasome system (UPS) in cardiac dise...
The overarching focus of this thesis is on the molecular underpinnings of inherited cardiomyopathies...
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder that associates with nucleotide ...
Aims: Previous studies have shown that hypertrophic cardiomyopathy mutation carriers have a decrease...
AIMS: Heart disease is commonly associated with altered mitochondrial function and signs of oxidativ...