Topics
geneOrganisation
MineraPlace
osteoclastAnatomical structure
glucocerebrosidaseBiomolecule
anemiaDisease
bone mineral densityDisease
Gaucher disease (GD) is caused by mutations on the gene encoding for the lysosomal enzyme glucocerebrosidase. Type I GD (GD1) patients present anemia, hepatosplenomegaly and bone alterations. In spite of treatment, bone alterations in GD patients persist, including poor bone mineral density (BMD). Mechanisms leading to bone damage are not completely understood, but previous reports suggest that osteoclasts are involved. Chitotriosidase (CHIT) is the most reliable biomarker used in the follow up of patients, although its correlation with bone status is unknown. The aim of this work was to study the pro-osteoclastogenic potential in patients and to evaluate its correlation with CHIT activity levels and clinical parameters. PBMCs from treated ...
Gaucher disease is a rare autosomal recessive disorder of glycosphingolipid metabolism resulting fro...
Context: Gaucher disease (GD) is a lysosomal storage disorder characterized by abundant presence of ...
Context: Gaucher disease (GD) is a lysosomal storage disorder characterized by abundant presence of ...
Gaucher disease (GD) is caused by mutations on the gene encoding for the lysosomal enzyme glucocereb...
Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a d...
Gaucher disease (GD) is caused by pathogenic mutations in GBA1, the gene that encodes the lysosomal ...
Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a d...
Gaucher disease is a lysosomal storage disorder caused by deficiency of glucocerebrosidase enzymatic...
Gaucher disease (GD) is caused by pathogenic mutations in GBA1, the gene that encodes the lysosomal ...
Gaucher disease (GD) is caused by mutations in the GBA gene that confer a deficient level of activit...
Gaucher, the most prevalent lysosomal disorder, is an autosomal recessive inherited disorder due to ...
Gaucher disease (GD) is caused by mutations in the GBA gene that confer a deficient level of activit...
Gaucher disease, the most common lysosomal storage disorder, is caused by ß-glucocerebrosidase defic...
Gaucher disease (GD) is an autosomal recessively inherited lysosomal disorder caused by mutations in...
Gaucher disease, the most common lysosomal storage disorder, is caused by β-glucocerebrosidase defic...
Gaucher disease is a rare autosomal recessive disorder of glycosphingolipid metabolism resulting fro...
Context: Gaucher disease (GD) is a lysosomal storage disorder characterized by abundant presence of ...
Context: Gaucher disease (GD) is a lysosomal storage disorder characterized by abundant presence of ...
Gaucher disease (GD) is caused by mutations on the gene encoding for the lysosomal enzyme glucocereb...
Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a d...
Gaucher disease (GD) is caused by pathogenic mutations in GBA1, the gene that encodes the lysosomal ...
Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a d...
Gaucher disease is a lysosomal storage disorder caused by deficiency of glucocerebrosidase enzymatic...
Gaucher disease (GD) is caused by pathogenic mutations in GBA1, the gene that encodes the lysosomal ...
Gaucher disease (GD) is caused by mutations in the GBA gene that confer a deficient level of activit...
Gaucher, the most prevalent lysosomal disorder, is an autosomal recessive inherited disorder due to ...
Gaucher disease (GD) is caused by mutations in the GBA gene that confer a deficient level of activit...
Gaucher disease, the most common lysosomal storage disorder, is caused by ß-glucocerebrosidase defic...
Gaucher disease (GD) is an autosomal recessively inherited lysosomal disorder caused by mutations in...
Gaucher disease, the most common lysosomal storage disorder, is caused by β-glucocerebrosidase defic...
Gaucher disease is a rare autosomal recessive disorder of glycosphingolipid metabolism resulting fro...
Context: Gaucher disease (GD) is a lysosomal storage disorder characterized by abundant presence of ...
Context: Gaucher disease (GD) is a lysosomal storage disorder characterized by abundant presence of ...
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