Enantioselective Synthesis of Spiro[indolizidine-1,3 '-oxindoles]
- Pérez Bosch, Maria
- Ramos, Carlos
- Massi, Lucia
- Gazzola, Silvia
- Taglienti, Chiara
- Yayik, Nihan
- Molins i Grau, Elies
- Viayna Gaza, Antonio
- Luque Garriga, F. Xavier
- Bosch Cartes, Joan
- Amat Tusón, Mercedes
Publication date
July 2020
DOI Publisher
American Chemical Society (ACS) Journal
Organic Letters Language
EnglishAbstract
A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported
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