Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation
- Wiersma, M. (Marit)
- Marion, D.M.S. (Denise) van
- Bouman, E.J.
- Li, J.
- Zhang, D.L.
- Ramos, K.S. (Kennedy)
- Lanters, E.A.H. (Eva)
- Groot, N.M.S. (Natasja) de
- Brundel, B.J.J.M. (Bianca)
DOIAbstract
Atrial fibrillation (AF), the most common, progressive tachyarrhythmia is associated with serious complications, such as stroke and heart failure. Early recognition of AF, essential to prevent disease progression and therapy failure, is hampered by the lack of accurate diagnostic serum biomarkers to identify the AF stage. As we previously showed mitochondrial dysfunction to drive experimental and human AF, we evaluated whether cell-free circulating
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