B Cells as Prognostic Biomarker After Surgery for Colorectal Liver Metastases

van 't Hof, J.
Visser, L.E. (Loes)
Hoppener, D.J.
van Nierop, P.M.M.
Terpstra, M.M.
Gouw, ASH
Grunhagen, D.J. (Dirk Jan)
Verhoef, C. (Kees)
Sijmons, RH
Jong, K.P. (Koert) de
Kok, K.

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Publication date

March 2020

DOI

10.3389/fonc.2020.00249

Publisher

Frontiers Media SA

Abstract

Background: The aim of this study was to identify more accurate variables to improve prognostication of individual patients with colorectal liver metastases (CRLM). Clinicopathological characteristics only partly explain the large range in survival rates. Methods: MessengerRNA expression profiles of resected CRLM of two patient groups were analysed by mRNA sequencing: poor survivors (death from recurrent disease 60 months after surgery). Tumour and adjacent liver parenchyma samples were analysed. Results: MessengerRNA expression profiling of the tumour samples identified 77 genes that were differentially expressed between the two survival groups at a False Discovery Rate (FDR) <0.1. In the adjacent liver parenchyma samples only one...