The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. Only a fraction of mutant meiocytes progress to form crossovers, which are crucial for chromosome segregation, demonstrating crossover homeostasis. Remarkably, loss of the DNA damage checkpoint kinase CHK2 rescues fertility in females without rescuing crossover numbers. Concomitant loss of the BRCA2 C terminus aggravates the meioti...
<div><p>Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segr...
Meiotic recombination is a fundamental biological process in sexually reproducing organisms, enablin...
Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor...
Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. ...
AbstractMeiotic recombination requires the meiosis-specific RecA homolog Dmc1 as well as the mitotic...
A distinguishing feature of meiotic DNA double-strand breaks (DSBs), compared to DSBs in somatic cel...
<div><p>The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA ...
textabstractMy PhD project encompassed studies on the functions of several different proteins, all i...
Eukaryotic meiotic recombination requires numerous biochemical processes, including break initiation...
Germ cell development and gametogenesis require genome-wide transitions in epigenetic modifications ...
Meiotic homologous recombination (HR) is important for proper chromosomal segregation during gametog...
RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA...
Free to read at publisher\ud \ud Homologous recombination is needed for meiotic chromosome segregati...
Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segregation ...
The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage i...
<div><p>Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segr...
Meiotic recombination is a fundamental biological process in sexually reproducing organisms, enablin...
Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor...
Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. ...
AbstractMeiotic recombination requires the meiosis-specific RecA homolog Dmc1 as well as the mitotic...
A distinguishing feature of meiotic DNA double-strand breaks (DSBs), compared to DSBs in somatic cel...
<div><p>The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA ...
textabstractMy PhD project encompassed studies on the functions of several different proteins, all i...
Eukaryotic meiotic recombination requires numerous biochemical processes, including break initiation...
Germ cell development and gametogenesis require genome-wide transitions in epigenetic modifications ...
Meiotic homologous recombination (HR) is important for proper chromosomal segregation during gametog...
RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA...
Free to read at publisher\ud \ud Homologous recombination is needed for meiotic chromosome segregati...
Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segregation ...
The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage i...
<div><p>Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segr...
Meiotic recombination is a fundamental biological process in sexually reproducing organisms, enablin...
Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor...