Importance: A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking. Objective: To determine the effects of intravenous zoledronic acid on knee cartilage volume loss in patients with symptomatic knee osteoarthritis and bone marrow lesions. Design, setting, and participants: A 24-month multicenter, double-blind placebo-controlled randomized clinical trial conducted at 4 sites in Australia (1 research center and 3 hospitals). Adults aged 50 years or older with symptomatic knee osteoarthritis and subchondral bone marrow lesions detected by magnetic resonance imaging (MRI) were enrolled from November ...
Purpose: Subchondral bone is becoming a treatment target for knee OA patients, with promising early ...
Bone marrow lesions (BML) represent areas of deteriorated bone structure and metabolism characterize...
Importance: Observational studies suggest that vitamin D supplementation is associated with benefits...
Importance: A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pa...
Abstract Background Bisphosphonates are a class of drugs that slow bone loss and are a promising can...
Background: Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate t...
Background: Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate t...
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plu...
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plu...
AbstrACt Objectives To compare the effect of a single infusion of zoledronic acid (ZA) with placebo ...
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plu...
Objective:To summarise effects of intravenous bisphosphonates (IVBP) in patients with symptomatic kn...
Objective. To determine whether atorvastatin slows tibial cartilage volume loss in patients with sym...
Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated w...
Objective: The aim of this study was to compare treatment methods of the knee joint degenerative ost...
Purpose: Subchondral bone is becoming a treatment target for knee OA patients, with promising early ...
Bone marrow lesions (BML) represent areas of deteriorated bone structure and metabolism characterize...
Importance: Observational studies suggest that vitamin D supplementation is associated with benefits...
Importance: A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pa...
Abstract Background Bisphosphonates are a class of drugs that slow bone loss and are a promising can...
Background: Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate t...
Background: Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate t...
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plu...
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plu...
AbstrACt Objectives To compare the effect of a single infusion of zoledronic acid (ZA) with placebo ...
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plu...
Objective:To summarise effects of intravenous bisphosphonates (IVBP) in patients with symptomatic kn...
Objective. To determine whether atorvastatin slows tibial cartilage volume loss in patients with sym...
Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated w...
Objective: The aim of this study was to compare treatment methods of the knee joint degenerative ost...
Purpose: Subchondral bone is becoming a treatment target for knee OA patients, with promising early ...
Bone marrow lesions (BML) represent areas of deteriorated bone structure and metabolism characterize...
Importance: Observational studies suggest that vitamin D supplementation is associated with benefits...