Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties

The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. Results show that hydrazide ligands (1-12) and their respective vanadium(V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and LOX, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds. 1 2017, Springer Science+Business Media, LLC.Acknowledgements S. Sultan is thankful to the Higher Education Commission for Indigenous Scholarship No. 112-34080-2PS1-155 under PhD Fellowships for 5000 scholars, HEC (Phase-II). Authors are thankful to the Higher Education Commission of Pakistan for financial support ('The National Research Grants Program for Universities', Grant No. 1862/R&D/10).Scopu