Bench-Stable Nickel Precatalysts with Heck-type Activation

Herein, we report the synthesis and characterization of a new class of air- and moisture-stable phosphine-containing nickel(II) precatalysts, which activate through a Heck-type mechanism. The activities of the precatalysts are demonstrated with a carbonyl-ene coupling reaction.NIGMS (Ruth L. Kirschstein National Research Service Award, no. F32GM120852)National Science Foundation (grant no. CHE-0946721