The anticancer drug, floxuridine, exhibits poor oral bioavailability partially due to extensive first pass metabolism by pyrimidine nucleoside phosphorylases to a less potent metabolite, 5-fluorouracil. The objective of this work was to design amino acid ester prodrugs of floxuridine to enhance intestinal absorption and minimize ester and glycosidic bond metabolism. In designing prodrugs to improve oral bioavailability, it was important to know what transporters or metabolizing enzymes prodrugs would encounter after reaching the absorptive surface of the intestine. Microarray expression profiling revealed that transporter expression in the Caco-2 cell model is most similar to that found in the human ileum. In terms of metabolizing enzyme ex...
AbstractNucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired ...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
The anticancer drug, floxuridine, exhibits poor oral bioavailability partially due to extensive firs...
Purpose. The aim of this study was to synthesize amino acid ester prodrugs of 5-fluoro-2′-deoxyuridi...
The aim of this study was to synthesize amino acid ester prodrugs of 5-fluoro-2′-deoxyuridine (floxu...
The researches were conducted to determine the advantages of prodrug approach over a parent drug. 5'...
The researches were conducted to determine the advantages of prodrug approach over a parent drug. 5'...
Floxuridine is a clinically proven anticancer agent in the treatment of metastatic colon carcinomas ...
A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the impro...
Floxuridine is a clinically proven anticancer agent in the treatment of metastatic colon carcinomas ...
A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the impro...
Purpose . To synthesize amino acid ester prodrugs of floxuridine (FUdR) and to investigate the effec...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
Nucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired immunode...
AbstractNucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired ...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
The anticancer drug, floxuridine, exhibits poor oral bioavailability partially due to extensive firs...
Purpose. The aim of this study was to synthesize amino acid ester prodrugs of 5-fluoro-2′-deoxyuridi...
The aim of this study was to synthesize amino acid ester prodrugs of 5-fluoro-2′-deoxyuridine (floxu...
The researches were conducted to determine the advantages of prodrug approach over a parent drug. 5'...
The researches were conducted to determine the advantages of prodrug approach over a parent drug. 5'...
Floxuridine is a clinically proven anticancer agent in the treatment of metastatic colon carcinomas ...
A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the impro...
Floxuridine is a clinically proven anticancer agent in the treatment of metastatic colon carcinomas ...
A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the impro...
Purpose . To synthesize amino acid ester prodrugs of floxuridine (FUdR) and to investigate the effec...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
Nucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired immunode...
AbstractNucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired ...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stabili...