Signal, noise, and detective quantum efficiency of amorphous-silicon:hydrogen flat-panel imagers.

Flat-panel imagers based upon the technology of thin-film amorphous silicon transistors and photodiodes are under investigation for a wide variety of medical imaging applications. This thesis presents quantitative empirical and theoretical investigations of the imaging performance of such imaging systems. Performance was evaluated in terms of imager signal size, spatial resolution, noise characteristics, and signal-to-noise ratio for a wide variety of imaging system configurations and exposure conditions relevant to medical imaging. A theoretical model based upon cascaded systems analysis allowed prediction of imager signal, noise, and detective quantum efficiency (DQE), and theoretical results were found to agree well with empirical measurements. The empirical and theoretical analyses yielded quantification of the performance of existing imager designs, allowed investigation of the potential performance of future flat-panel imaging systems, and provided a methodology for identifying optimal imager configurations for various applications and imaging tasks. There is every indication that flat-panel imagers could provide performance superior to that of existing clinical imaging technologies. For example, in general x-ray radiography, mammography, and radiotherapy portal imaging, such systems could provide DQE exceeding 60%, 80%, and 1.5%, respectively, approximately twice that of film-based systems. However, for applications involving very low exposures per image, e.g., real-time fluoroscopy, such systems may suffer from reduced signal-to-noise ratio. The analyses developed in this thesis provide an effective means of identifying strategies for improved imager performance and will facilitate the realization of optimized flat-panel imagers that physically achieve their maximum theoretical performance.PhDApplied SciencesBiomedical engineeringCondensed matter physicsElectrical engineeringPure SciencesUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/131326/2/9840647.pd