Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment; however, a third of patients fail to achieve therapeutic responses. Unexpectedly, studies in murine and human arthritis have indicated that anti-TNF treatment can increase circulating T helper 17 (Th17) cells, but the relationship to treatment response is unclear. To identify immune correlates of anti-TNF treatment response, we conducted a longitudinal study using clinical, ultrasound and T cell assessments. Methods Patients with RA (n = 25) were studied at protocol visits during the initial 12 weeks of anti-TNF treatment. Improvement in the disease activity score of 28 joints (DAS28) >1.2 defined treatment responders (n = 16) and non-responders (n = 9). Cha...
Improved understanding of the immune events discriminating between seropositive arthralgia and clini...
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic ...
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic ...
Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment; however, a third...
Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment; however, a third...
Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment, however a third ...
Anti-TNF agents have revolutionised the treatment of rheumatoid arthritis (RA), ankylosing spondylit...
Objective: To examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA ...
OBJECTIVES: To establish if changes in Th1/Th17 cell populations previously reported in experimental...
Objectives: To establish if changes in Th1/Th17 cell populations previously reported in experimental...
Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although ...
The importance of IL-17 is underscored both by its resistance to control by regulatory T cells (Treg...
Power Doppler ultrasound (PDUS) is increasingly used to assess synovitis in Rheumatoid Arthritis (RA...
Introduction\ud Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). Th...
AbstractAim of the workTo investigate the role of T-helper 17 (Th17) cells in peripheral blood and s...
Improved understanding of the immune events discriminating between seropositive arthralgia and clini...
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic ...
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic ...
Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment; however, a third...
Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment; however, a third...
Background Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment, however a third ...
Anti-TNF agents have revolutionised the treatment of rheumatoid arthritis (RA), ankylosing spondylit...
Objective: To examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA ...
OBJECTIVES: To establish if changes in Th1/Th17 cell populations previously reported in experimental...
Objectives: To establish if changes in Th1/Th17 cell populations previously reported in experimental...
Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although ...
The importance of IL-17 is underscored both by its resistance to control by regulatory T cells (Treg...
Power Doppler ultrasound (PDUS) is increasingly used to assess synovitis in Rheumatoid Arthritis (RA...
Introduction\ud Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). Th...
AbstractAim of the workTo investigate the role of T-helper 17 (Th17) cells in peripheral blood and s...
Improved understanding of the immune events discriminating between seropositive arthralgia and clini...
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic ...
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic ...