Oxindole and isatin derivatives and their application in organocatalyzed transformations – synthesis of 5-fluoroindoline -2,3-dione derived isothiocyanates

V diplomskem delu sem predstavil organokatalizo, na kratko preletel nekaj pomembnejših odkritij na področju organokatalize ter opisal nekaj bolj razširjenih metod organokatalize. Kot izhodne spojine v organokatalizi sem predstavil oksindol, isatin in njune derivate ter sintezo le-teh. Sinteza derivatov oksindola ter isatina je v današnjem času privlačna predvsem zaradi njihove biološke aktivnosti. Mnogi derivati se prav zaradi tega lahko uporabljajo kot učinkovine v zdravilih. Podrobneje sem predstavil tudi sintezo izotiocianata na osnovi 5-fluoroindolin-2,3-diona.This work explores organocatalysis, some of the more significant advances in organocatalysis throughout history and methods most commonly used in various organocatalytic reactions. The use of oxindole, isatin and their derivatives as starting compounds in the field of organocatalysis is very prevalent because of their bioactivity. Furthermore, many derivatives are, for the reasons listed, used as pharmaceuticals in various drugs. In addition, the synthesis of 5-fluoroindoline-2,3-dione derived isothiocyanates are presented in more detail