Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study

BACKGROUND: Insulin resistance (IR) and progressive pancreatic beta-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in nondiabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI >= 30 kg/m(2)) with no diabetes mellitus (fasting glucose levels <= 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-beta indexes. The area under the curve (AUC) of the variables was compared. The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-beta and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-beta, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73). The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-beta. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo Unifesp, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Dept Human Movement Sci, Sao Paulo, SP, BrazilAngiocorpore Inst Med Cardiovasc, Dept Cardiovasc Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo Unifesp, Postgrad Program Food Nutr & Hlth, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Lab Epidemiol & Human Movement, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Human Movement Sci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Dept Human Movement Sci, Sao Paulo, SP, BrazilFed Univ Sao Paulo Unifesp, Postgrad Program Food Nutr & Hlth, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Lab Epidemiol & Human Movement, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Human Movement Sci, Sao Paulo, SP, BrazilFAPESP: 2011/07282-6Web of Scienc