Cortical thickness in obsessive compulsive disorder: multisite mega-analysis of 780 brain scans from six centres
- Fouche, Jean-Paul
- du Plessis, Stefan
- Hattingh, Coenie
- Roos, Annerine
- Lochner, Christine
- Soriano-Mas, Carles
- Sato, Joao Ricardo [UNIFESP]
- Nakamae, Takashi
- Nishida, Seiji
- Kwon, Jun Soo
- Jung, Wi Hoon
- Mataix-Cols, David
- Hoexter, Marcelo Queiroz [UNIFESP]
- Alonso, Pino
- de Wit, Stella J.
- Veltman, Dick J.
- Stein, Dan J.
- van den Heuvel, Odile A.
DOIAbstract
Background There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive -compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. Aims To investigate alterations in cortical thickness and subcortical volume in OCD. Method In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. Results Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precun...
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