Interactions of membrane transporters with drugs in the placenta and pancreatic ductal adenocarcinoma

Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lucie Jirásková Supervisor: doc. PharmDr. Lukáš Červený, Ph.D. Title of doctoral thesis: Interactions of membrane transporters with drugs in the placenta and pancreatic ductal adenocarcinoma Membrane transporters are found throughout the body, where they are responsible for many vital functions. Important representatives of membrane transporters are P-glycoprotein (ABCB1), Breast cancer resistance protein (ABCG2) and multidrug resistance-associated protein 2 (ABCC2) belonging to the ATP-biding Cassette (ABC) family. Nucleoside transporters belonging to Solute Carriers family (SLC) transporters represent another important group. It has been well evidenced that these transporters also affect drug disposition and contribute to tumor resistance to anticancer therapy. Over working on this dissertation thesis, we investigated the mentioned transporters (with special focus on nucleoside transporters) in complex fashion. We described the expression profile of nucleoside transporters in the placenta at different stages of gestation. We also examined whether the expression of nucleoside transporters changes depending on the degree of differentiation or can be affected epigenetically, and we..