Cholesterol is an essential biological molecule, important in maintaining cell membrane integrity and fluidity, cell signalling, and being a precursor for bile acids and steroid hormones. However, high cholesterol levels correlate with several disease states, including heart disease, cancer and neurodegeneration. The cell therefore tightly regulates cholesterol levels at both the transcriptional and post-translational levels. Cholesterol synthesis involves over 20 enzymatic reactions. Previously, research focused on 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the first control point in cholesterol synthesis. However, our lab recently identified a second rate-limiting step, catalysed by squalene monooxygenase (SM). Statins, the choles...
Squalene monooxygenase (SM) is an important control point in cholesterol synthesis beyond 3-hydroxy-...
Cholesterol is essential for normal growth and development in both man and mouse. However, excess ch...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...
Exquisite control of cholesterol synthesis is crucial for maintaining homeostasis of this vital yet ...
SummaryExquisite control of cholesterol synthesis is crucial for maintaining homeostasis of this vit...
In humans, cholesterol is a vital lipid, essential for the structure and function of cell membranes,...
Cholesterol is a vital lipid required for many biological processes including the maintenance of cel...
The maintenance of intracellular cholesterol homeostasis relies on a fascinating interplay between m...
Cholesterol is an essential lipid associated with many important biological functions. At both the c...
Supernatant protein factor (SPF) is a 46-kDa cytosolic protein that stimulates squalene monooxygenas...
Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a clas...
AbstractCholesterol is one of the key constituents for maintaining the cellular membrane and thus th...
Background and aims: Cholesterol is an essential lipid for cellular function and membrane integrity,...
Cellular cholesterol homeostasis ensures that cells are able to acquire enough cholesterol for cellu...
Themevalonate pathway is used by cells to produce sterol and nonsterol metabolites and is subject to...
Squalene monooxygenase (SM) is an important control point in cholesterol synthesis beyond 3-hydroxy-...
Cholesterol is essential for normal growth and development in both man and mouse. However, excess ch...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...
Exquisite control of cholesterol synthesis is crucial for maintaining homeostasis of this vital yet ...
SummaryExquisite control of cholesterol synthesis is crucial for maintaining homeostasis of this vit...
In humans, cholesterol is a vital lipid, essential for the structure and function of cell membranes,...
Cholesterol is a vital lipid required for many biological processes including the maintenance of cel...
The maintenance of intracellular cholesterol homeostasis relies on a fascinating interplay between m...
Cholesterol is an essential lipid associated with many important biological functions. At both the c...
Supernatant protein factor (SPF) is a 46-kDa cytosolic protein that stimulates squalene monooxygenas...
Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a clas...
AbstractCholesterol is one of the key constituents for maintaining the cellular membrane and thus th...
Background and aims: Cholesterol is an essential lipid for cellular function and membrane integrity,...
Cellular cholesterol homeostasis ensures that cells are able to acquire enough cholesterol for cellu...
Themevalonate pathway is used by cells to produce sterol and nonsterol metabolites and is subject to...
Squalene monooxygenase (SM) is an important control point in cholesterol synthesis beyond 3-hydroxy-...
Cholesterol is essential for normal growth and development in both man and mouse. However, excess ch...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...