Exploring Analgesic Prospective of Hydroalcoholic Extract of Lagerstroemia speciosa Root in Swiss Albino Rats

Lagerstroemia speciosa belonging to the family of Lythraceae is a medium to large size (30-35 m) plant of a semi-deciduous type that is majorly found in subtropical and tropical areas of the world such as South and South-East Asia. After exploring numerous pharmaceutical databases such as PubMed, Google Scholar, etc., it was observed that no analgesic screening of the root methanolic extract of L. speciosa have been performed to date in Swiss albino rats. The current investigation involved determining the analgesic potentials of root methanolic extract of L. speciosa (RELS) in acetic acid-induced writhing inhibition method in Swiss albino rats. The hydroalcoholic extract produced 41.77% inhibition of writhing at a dose of 500 mg/kg b.w. as compared to the standard drug which displayed 52.19% writhing inhibition at a dose of 25 mg/kg b.w. The presence of phytochemicals such as flavonoids, tannins, alkaloids, and phenolic principles may be believed to play a major role in expressing analgesia in the subjects. The preliminary exploration opened the latest possibilities of herbal or natural products-based analgesic pharmacotherapeutics. However, this supplementary investigation is fundamentally necessitated in developing pharmaceutical formulations for pain-relieving applications