We have defined the chromosomal location of the human MAGE (melanoma antigen) gene family by polymerase chain reaction amplification of several segments of the MAGE genes from somatic cell hybrids containing well-defined groups of human chromosomes and hybrids containing human derivative chromosomes. The data show that the three known MAGE family members (MAGEs -1, -2, & -3) are syntenic and map to the human X chromosome region q27-qter. Because males and females are hemizygous for most X-linked genes, the frequency of antigen-loss variants for the MAGE system is expected to be greater in comparison to antigens encoded by somatic chromosomes. In this regard, we believe that patients enrolled in MAGE-specific immunotherapy trials should be c...
The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using revers...
The first human members of the MAGE gene family that have been described are expressed in tumor cell...
The first human members of the MAGE gene family that have been described are expressed in tumor cell...
We have defined the chromosomal location of the human MAGE (melanoma antigen) gene family by polymer...
We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized o...
We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized o...
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are ...
MAGE1 encodes a tumor specific antigen MZ2-E that elicited a cytotoxic T lymphocytic response (CTL) ...
The evolutionary mode of a multi-gene family can change over time, depending on the functional diffe...
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are ...
peer reviewedGenes of the MAGE family direct the expression of tumor antigens recognized on a ...
The evolutionary mode of a multi-gene family can change over time, depending on the functional diffe...
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are ...
Genes of the MAGE family direct the expression of tumor antigens recognized on a human melanoma by a...
Genes of the MAGE family direct the expression of tumor antigens recognized on a human melanoma by a...
The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using revers...
The first human members of the MAGE gene family that have been described are expressed in tumor cell...
The first human members of the MAGE gene family that have been described are expressed in tumor cell...
We have defined the chromosomal location of the human MAGE (melanoma antigen) gene family by polymer...
We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized o...
We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized o...
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are ...
MAGE1 encodes a tumor specific antigen MZ2-E that elicited a cytotoxic T lymphocytic response (CTL) ...
The evolutionary mode of a multi-gene family can change over time, depending on the functional diffe...
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are ...
peer reviewedGenes of the MAGE family direct the expression of tumor antigens recognized on a ...
The evolutionary mode of a multi-gene family can change over time, depending on the functional diffe...
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are ...
Genes of the MAGE family direct the expression of tumor antigens recognized on a human melanoma by a...
Genes of the MAGE family direct the expression of tumor antigens recognized on a human melanoma by a...
The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using revers...
The first human members of the MAGE gene family that have been described are expressed in tumor cell...
The first human members of the MAGE gene family that have been described are expressed in tumor cell...