GENETIC MUSCLE DISEASES: NEW INSIGHT INTO THE BASIS OF THE MYOTONIC DYSTROPHIES

Neuromuscular diorders can be divided into 1) myopathies, primary disease of themuscle fiber, 2) myasthenias, diseases caused by defects of the neuromuscular junction and 3)neurogenic muscular atrophies, caused by the defects of the motor nerve. Musculardystrophies are a heterogeneous group of myopathies. They are genetic disorders caused bymuscle fiber degeneration often causing progressive weakness and wasting and they can befurther divided into the followingMyotonic dystrophies – DM1 andDM2Dystrophinopathies - DMD, BMDFacioscapulohumeral - FSHDLimb-girdle – LGMD subtypesDistal muscular dystrophiesCongenital dystrophies - CMDOculofaryngeal - OPM, OPDMEmery-Dreifuss - X-EMD, AD-EMDOther and unclassified muscular dystrophie