Pharmaceutical green chemistry in peptide synthesis A snapshot on the role of solvents in SPPS

Solid phase peptide synthesis (SPPS) is a widely used technology for the production of peptides at lab and industrial level. During the last 15 years several research groups worked on the development of environmentally friendly protocols for large scale production. New protective groups as well as coupling agents have been introduced at industrial level. In the attempt to make greener the SPPS technology, several more sustainable solvents have been proposed to replace the reprotoxic DMF or NMP and to limit acetonitrile/water for the purification step. In this work, the results of these studies have been summarized to outline future possible scenarios in pharmaceutical drug manufacturin