Albuminuria and cardiovascular events in patients with acute coronary syndromes: Results from the TRACER trial
- Akerblom A.
- Clare R. M.
- Lokhnygina Y.
- Wallentin L.
- Held C.
- Van De Werf F.
- Moliterno D. J.
- Patel U. D.
- Leonardi S.
- Armstrong P. W.
- Harrington R. A.
- White H. D.
- Aylward P. E.
- Mahaffey K. W.
- Tricoci P.
DOIAbstract
Background Albuminuria is associated with cardiovascular (CV) outcomes. We evaluated albuminuria, alone and in combination with estimated glomerular filtration rate (EGFR), as a predictor of mortality and CV morbidity in 12,944 patients with non-ST-segment elevation acute coronary syndromes. Methods Baseline serum creatinine and urinary dipsticks were obtained, with albuminuria stratified into no/trace albuminuria, microalbuminuria (≥30 but <300 mg/dL), or macroalbuminuria (≥300 mg/dL). Kaplan-Meier rates and proportional Cox hazards models of CV death, overall mortality, CV death or myocardial infarction (MI), and bleeding were calculated. Incidence of acute kidney injury, identified by adverse event reporting and creatinine increase (abso...
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