The sinus node is a collection of highly specialised cells constituting the heart’s pacemaker. The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution mass spectrometry, we here quantify >7,000 proteins from sinus node and neighbouring atrial muscle. Abundances of 575 proteins differ between the two tissues. By performing single-nucleus RNA sequencing of sinus node biopsies, we attribute measured protein abundances to specific cell types. The data reveal significant differences in ion channels responsible for the membrane clock, but not in Ca2+ clock proteins, suggesting that the membrane clock nderpins pacemaking. Consistently, incorporation of ion channel expression differences into a biophysically-deta...
open4siKey points: We constructed a comprehensive mathematical model of the spontaneous electrical a...
The rate of contraction of the heart relies on proper development and function of the sinoatrial nod...
Background: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart's primary ...
BACKGROUND: Although we know much about the molecular makeup of the sinus node (SN) in small mammals...
Background-Although we know much about the molecular makeup of the sinus node (SN) in small mammals,...
BackgroundAlthough we know much about the molecular makeup of the sinus node (SN) in small mammals, ...
BACKGROUND: Although we know much about the molecular makeup of the sinus node (SN) in small mammals...
Rationale: Treatment of sinus node disease with regenerative or cell-based therapies will require a ...
RationaleTreatment of sinus node disease with regenerative or cell-based therapies will require a de...
Normal cardiac automaticity is dependent on the pacemaker cells of the sinoatrial node (SAN). Insuff...
BACKGROUND: The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distincti...
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly hete...
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly hete...
There are few models of the human cardiac action potential, because it is difficult to obtain human ...
Cardiac pacemaking in the sinoatrial (SA) node and atrioventricular (AV) node is generated by an int...
open4siKey points: We constructed a comprehensive mathematical model of the spontaneous electrical a...
The rate of contraction of the heart relies on proper development and function of the sinoatrial nod...
Background: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart's primary ...
BACKGROUND: Although we know much about the molecular makeup of the sinus node (SN) in small mammals...
Background-Although we know much about the molecular makeup of the sinus node (SN) in small mammals,...
BackgroundAlthough we know much about the molecular makeup of the sinus node (SN) in small mammals, ...
BACKGROUND: Although we know much about the molecular makeup of the sinus node (SN) in small mammals...
Rationale: Treatment of sinus node disease with regenerative or cell-based therapies will require a ...
RationaleTreatment of sinus node disease with regenerative or cell-based therapies will require a de...
Normal cardiac automaticity is dependent on the pacemaker cells of the sinoatrial node (SAN). Insuff...
BACKGROUND: The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distincti...
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly hete...
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly hete...
There are few models of the human cardiac action potential, because it is difficult to obtain human ...
Cardiac pacemaking in the sinoatrial (SA) node and atrioventricular (AV) node is generated by an int...
open4siKey points: We constructed a comprehensive mathematical model of the spontaneous electrical a...
The rate of contraction of the heart relies on proper development and function of the sinoatrial nod...
Background: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart's primary ...