Thrombotic risk in COVID-19: a case series and case-control study
- Stoneham, Simon M
- Milne, Kate M
- Nuttal, Elisabeth
- Frew, Georgina H
- Sturrock, Beattie R
- Sivaloganathan, Helena
- Ladikou, Eleni E
- Drage, Stephen
- Phillips, Barbara
- Chevassut, Timothy J T
- Eziefula, Alice C
DOIAbstract
Background: A possible association between COVID-19 infection and thrombosis, either as a direct consequence of the virus or as a complication of inflammation, is emerging in the literature. Data on the incidence of venous thromboembolism (VTE) is extremely limited. Methods: We describe 3 cases of thromboembolism refractory to heparin treatment, the incidence of VTE in an inpatient cohort, and a case-control study to identify risk factors associated with VTE. Results: We identified 274 confirmed (208) or probable (66) COVID-19 patients. 21 (7.7%) were diagnosed with VTE. D-dimer was elevated in both cases (confirmed VTE) and controls (no confirmed VTE) but higher levels were seen in confirmed VTE cases (4.1vs 1.2 µg/mL P <0.001). C...
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