Mukopenetrativne nanočestice - nov terapijski sustav za dostavu lijeka putem sluznica

Mucus is a viscoelastic and adhesive gel layer that protects eye, respiratory, gastrointestinal, reproductive tract and other mucosal surfaces of the human body. The most of foreign particles such as dust and microbes, as well as particle-based drug delivery system are efficiently trapped in the mucus by adhesion and steric obstruction and then removed from the mucosal tissues in time intervals ranging from minutes to several hours. A number of diseases and conditions, including chronic rhinitis, cystic fibrosis, inflammatory bowel disease, glaucoma, lung or colon cancer, glaucoma and sexually transmitted diseases could be treated more efficiently and with fewer side effects if the drug could be delivered to the underlying mucosal tissue in a controlled manner. Drug loaded mucoadhesive nanoparticles with 11011-adhesive coating or nanoparticles bearing the mucolytic enzymes, possessing the ability to rapidly penetrate mucus layer nearly as fast as they would penetrate pure water, are potential delivery system in this regard. This article presents a short overview of the mucus barrier properties and current technologies used to obtain the mucopenetration of nanoparticles