Citokrom P450 i metabolizam lijekova - značenje i novosti

Cytochrome P450 enzymes are the most important enzyme superfamily for metabolism of xenobiotics. In the last few years, knowledge on metabolism of xenobiotics has grown exponentially. In this paper cytochrome P450 I A2, 2A6, 2C8, 2C9, 2C 19, 206, 2E I , 3A4 and 3A5 substrates, inhibitors and inductors are reviewed with special focus on marker reactions of individual P4 50s