Add to ORKGIn addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing molecules. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2 min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCOprodrug in live macrophages. Overall, this work expands the scope of functional groups a...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involv...
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has ...
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has ...
Bioorthogonal decaging reactions have emerged as a promising strategy for the spatially and temporal...
The inverse-electron-demand Diels-Alder (iDA) reaction has recently been repurposed as a bioorthogon...
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involv...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
Recent developments in bond cleavage reactions have expanded the scope of bioorthogonal chemistry be...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involv...
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has ...
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has ...
Bioorthogonal decaging reactions have emerged as a promising strategy for the spatially and temporal...
The inverse-electron-demand Diels-Alder (iDA) reaction has recently been repurposed as a bioorthogon...
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involv...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The high rate of the 'click-to-release' reaction between an allylic substituted trans-cyclooctene li...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
Recent developments in bond cleavage reactions have expanded the scope of bioorthogonal chemistry be...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables acc...
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involv...