Add to ORKGAllyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second generation catalyst 1. The high reactivity of allyl sulfides in cross-metathesis was exploited in the first examples of cross-metathesis on a protein surface. S-Allylcysteine was incorporated chemically into the protein, providing the requisite allyl sulfide handle. Preliminary efforts to genetically incorporate S-allylcysteine into proteins are also reported. Copyright © 2008 American Chemical Society
Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several m...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Site-selective protein modification has become an important tool to study protein functions in chemi...
Site-selective protein modification has become an important tool to study protein functions in chemi...
Olefin metathesis has become a mainstay in organic synthesis.1 Cross-metathesis (CM), however, is la...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin metathesis has recently emerged as a viable reaction for chemical protein modification. The s...
Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cyst...
Allyl sulfides have gained traction in recent years as promoters for olefinmetathesis. The high reac...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several m...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Site-selective protein modification has become an important tool to study protein functions in chemi...
Site-selective protein modification has become an important tool to study protein functions in chemi...
Olefin metathesis has become a mainstay in organic synthesis.1 Cross-metathesis (CM), however, is la...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin metathesis has recently emerged as a viable reaction for chemical protein modification. The s...
Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cyst...
Allyl sulfides have gained traction in recent years as promoters for olefinmetathesis. The high reac...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several m...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...