A Novel Copper(II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase II alpha
- Sandhaus, Shayna
- Taylor, Rosella
- Edwards, Tiffany
- Huddleston, Alexis
- Wooten, Ykeysha
- Venkatraman, Ramaiyer
- Weber, Ralph T.
- Gonzalez-Sarrias, Antonio
- Martin, Patrick M.
- Cagle, Patrice
- Tse-Dinh, Yuk-Ching
- Beebe, Stephen J.
- Seeram, Navindra
- Holder, Alvin A.
DOIAbstract
A novel complex, [Cu(acetylethTSC)Cl]Cl·0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects. (C) 2015 Elsevier B.V. All rights reserved
Add to ORKG