Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes

Lekva, T.
Sugulle, M.
Moe, K.
Redman, C.
Dechend, R.
Staff, A.C.

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Publication date

June 2020

DOI

10.1161/HYPERTENSIONAHA.119.14580

Publisher

American Heart Association

Abstract

Preeclampsia, a hypertensive pregnancy disorder, links to increased long-term maternal cardiovascular disease (CVD). The risk is further increased with early-onset preeclampsia (EPE) and delivery of a growth-restricted child. We hypothesized that circulating biomarkers associated with CVD risk differed between preeclampsia subtypes and controls. We compared EPE; n=37, delivery <week 34, late-onset preeclampsia (LPE); n=29, delivery ≥week 34, and normotensive controls (n=49) using Olink Proseek multiplex CVD I assay (targeting 92 biomarkers). We stratified analysis to uteroplacental spiral artery acute atherosis presence in preeclampsia patients, sharing morphological similarities with atherosclerosis. We found 47 CVD-related biomarkers diff...