Management of women with an unexpected low ovarian response to gonadotropin
- Conforti, Alessandro
- Esteves, Sandro C.
- Cimadomo, Danilo
- Vaiarelli, Alberto
- Di Rella, Francesca
- Ubaldi, Filippo Maria
- Zullo, Fulvio
- De Placido, Giuseppe
- Alviggi, Carlo
DOIAbstract
POSEIDON groups 1 and 2 patients respond poorly (<4 oocytes retrieved) or sub-optimally (4-9 oocytes retrieved) to gonadotropin stimulation despite the presence of adequate ovarian parameters, which negatively affect their cumulative chances of delivering a baby using Assisted Reproductive Technology. A polygenic trait involving gonadotropins and/or their receptors seems to be the primary pathophysiology mechanism explaining this phenomenon. The clinical management is mainly focused on maximizing oocyte yield as to increase the likelihood of having at least one euploid embryo for transfer. Indices such as FORT (follicle output rate) and FOI (follicle-to-oocyte index) may be used to determine if the ovarian reserve was properly explored duri...
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