Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
- Antunes, Krist Helen
- Fachi, Jose Luis
- de Paula, Rosemeire
- da Silva, Emanuelle Fraga
- Pral, Lais Passariello
- dos Santos, Adara Aurea
- Malaquias Dias, Greicy Brisa
- Vargas, Jose Eduardo
- Puga, Renato
- Mayer, Fabiana Quoos
- Maito, Fabio
- Zarate-Blades, Carlos R.
- Ajami, Nadim J.
- St Ana, Marcella Ramos
- Candreva, Thamiris
- Rodrigues, Hosana Gomes
- Schmiele, Marcio
- Pedrosa Silva Clerici, Maria Teresa
- Proenca-Modena, Jose Luiz
- Vieira, Angelica Thomas
- Mackay, Charles R.
- Mansur, Daniel
- Caballero, Mauricio T.
- Marzec, Jacqui
- Li, Jianying
- Wang, Xuting
- Bell, Douglas
- Polack, Fernando P.
- Kleeberger, Steven R.
- Stein, Renato T.
- Ramirez Vinolo, Marco Aurelio
- Duarte de Souza, Ana Paula
DOIAbstract
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-beta (IFN-beta) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary ep...
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