L’instabilité des microsatellites (MSI) est un phénotype tumoral dû à une déficience héréditaire ou acquise du système de réparation des mésappariements de l’ADN (MMR : mismatch repair). Le phénotype MSI est retrouvé dans 5% des cancers colorectaux métastatiques (CCRm) et est un facteur prédictif positif majeur de l’efficacité des inhibiteurs de checkpoints immunitaires (ICKi). L’objectif de mon travail a été de caractériser sur le plan clinique et moléculaire les CCRm MSI, d’en évaluer les modalités diagnostiques et d’évaluer la réponse aux ICKi. Dans un 1er travail, je montre que l’histoire naturelle clinique des CCRm MSI diffère selon le mécanisme sporadique ou héréditaire de la déficience MMR (Cohen et al., Eur J Cancer 2017). Dans un 2...
Microsatellite instability (MSI) is a common tumor phenotype associated with many human cancers. It ...
Since the discovery of a link between mismatch repair (MMR) deficiency and cancer, microsatellite in...
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite inst...
Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which...
Microsatellite instability (MSI), the molecular phenotype of colorectal cancers with mismatch repair...
Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which...
Microsatellite instability (MSI) is the landmark feature of DNA mismatch repair deficiency, which c...
L’instabilité des séquences répétées microsatellites du génome (courtes répétitions en tandem d’un à...
Microsatellite instability (MSI), the molecular phenotype of colorectal cancers with mismatch repair...
Identification and understanding of the molecular events involved in colorectal cancer (CRC) pathog...
Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR) system a...
Microsatellite instability (MSI) has been a promising molecular marker in colorectal cancer over the...
Background: patients (pts) with metastatic colorectal cancers (mCRC) harbouring microsatellite insta...
L'instabilité des séquences microsatellites de l’ADN (MSI) signe un phénotype tumoral fréquent assoc...
Microsatellite instability (MSI) is a marker of the replication error phenotype. It is caused by imp...
Microsatellite instability (MSI) is a common tumor phenotype associated with many human cancers. It ...
Since the discovery of a link between mismatch repair (MMR) deficiency and cancer, microsatellite in...
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite inst...
Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which...
Microsatellite instability (MSI), the molecular phenotype of colorectal cancers with mismatch repair...
Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which...
Microsatellite instability (MSI) is the landmark feature of DNA mismatch repair deficiency, which c...
L’instabilité des séquences répétées microsatellites du génome (courtes répétitions en tandem d’un à...
Microsatellite instability (MSI), the molecular phenotype of colorectal cancers with mismatch repair...
Identification and understanding of the molecular events involved in colorectal cancer (CRC) pathog...
Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR) system a...
Microsatellite instability (MSI) has been a promising molecular marker in colorectal cancer over the...
Background: patients (pts) with metastatic colorectal cancers (mCRC) harbouring microsatellite insta...
L'instabilité des séquences microsatellites de l’ADN (MSI) signe un phénotype tumoral fréquent assoc...
Microsatellite instability (MSI) is a marker of the replication error phenotype. It is caused by imp...
Microsatellite instability (MSI) is a common tumor phenotype associated with many human cancers. It ...
Since the discovery of a link between mismatch repair (MMR) deficiency and cancer, microsatellite in...
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite inst...