The analysis of the pathogenetic factors for the psychosocial maladaptation formation in patients with alcohol dependence

The search for early diagnostic markers of the psychosocial maladaptation formation in alcohol dependence to optimize the treatment, rehabilitation and preventive measures in this cohort of patients is one of the urgent tasks of the contemporary narcology to date.The purpose of the paper was to reveal the significant pathogenetic factors for the psychosocial maladaptation formation in patients with alcohol dependence. 290 male patients with alcohol dependence, aged 23 to 59 years have been involved into the comprehensive study that has been carried out using the clinicopsychopathological, psychodiagnostic, neuropsychological, biochemical and statistical methods. To determine the characterological features the Leonhard-Schmieschek questionnaire has been used; neuropsychological study has been conducted using the method, developed by O.R. Luria; the level of neuropsychological deficit has been assessed using the І. F. Roschina’s rating scale; the research on social indicators to determine the level of maladaptation has been made using the questionnaire of N.K. Liphardt, V.P. Radchenko; the diagnostics of the states of hormonal regulation of carbohydrate metabolism has been made according to the criteria, developed by Ya. I. Tomashevskii, O.Ya. Tomashevska; statistical data processing has been done using the factor and discriminant analyses. Multicentric study has been carried out to identify the common peculiarities of the pathogenic mechanisms of the psychosocial maladaptation formation in patients with alcohol dependence, which permitted to distinguish six main factors, i.e., factors of neurocognitive deficit, the state of carbohydrate metabolism, the level of maladaptation, physico-typological features, the clinical manifestations and hereditary load. The findings of the discriminant analysis have defined a list of variables that have the most significant impact on the patient classification according to the groups depending on the stage and physico-typological features, confirming the findings of the multicentric study. The findings of the research have presented the groups of indices that elucidated the main pathogenetic mechanisms of the maladaptation formation in patients with alcohol dependence. The resulting data complement the existing views on the common pathogenetic mechanisms of the development of alcohol dependence